Table 2. CP inhibitors.
| Inhibitor | Targeted enzyme | Organisms/disease | References |
|---|---|---|---|
| K11777 | Cruzain, TcCatL, cryptopains, TgCPL, TgCPB, EhCP1, LtCP | Trypanosoma cruzi, T. brucei, Cryptosporidium parvum, Toxoplasma gondii, Entamoeba histolytica, Leishmania tropica | [2, 19, 60, 91, 149] |
| WRR-483 | Cruzain, EhCP1 | T. cruzi, E. histolytica | [19, 82, 154–156] |
| Cz007, Cz008 | Cruzain | T. cruzi | [81] |
| Gallinamide A | Falcipain-2, falcipain-3 | Plasmodium falciparum | [128] |
| Symplostatin 4 | Falcipain | P. falciparum | [157] |
| Tetrafluorophenoxymethyl ketone | Cruzain | T. cruzi | [158] |
| Odanacatib | Human cathepsin K | osteoporosis | [159] |
| Balicatib | Human cathepsin K | osteoporosis | [160] |
| Emricasan | Human caspase-8 | Liver protection, leukemia | [161] |
| SAR114137 | Human cathepsin S | Chronic pain | https://ncats.nih.gov/files/SAR114137.pdf |
| RWJ-445380 | Human cathepsin S | Rheumatoid arthritis | https://ncats.nih.gov/files/RWJ-445380.pdf |
Abbreviation: CP, cysteine protease.