Table 6. Characteristics of subjects undergoing PCI or CABG and those with MI or death from cardiovascular cause before age 50.
| Variable | All cases n = 2939 |
PCI/CABG n = 1315 (45%) |
MI/Death n = 1624 (55%) |
Difference PCI/CABG and MI/death (p Value) |
|||
|---|---|---|---|---|---|---|---|
| Years to event (median, (range)) |
8 (4–14) | 11 (7–16) | 6 (3–11) | <0.001 | |||
| Age years (mean (SD)) | 45.4 (4.21) | 45.9 (3.4) | 44.9 (4.7) | <0.001 | |||
| Fredrickson Classification | (%) | (%) | (%) | ||||
| IIa (TC ≥ 5, TG <1.7) | 1132/2918 | 38.8 | 491/1304 | 37.7 | 641/1614 | 39.7 | 0.07 |
| IIb (TC ≥ 5, TG ≥1.7) | 1198/2918 | 41.1 | 570/1304 | 43.7 | 628/1614 | 38.9 | <0.001 |
| IV (TC < 5, TG ≥1.7) | 105/2918 | 3.6 | 47/1304 | 3.6 | 58/1614 | 3.6 | nc |
| TC < 5, TG <1.7 | 483/2918 | 16.6 | 196/1304 | 15.0 | 287/1614 | 17.8 | 0.003 |
| Female | 517/2939 | 17.6 | 185/1315 | 14.1 | 332/1315 | 20.4 | <0.001 |
| High glucose levela | 348/2766 | 12.6 | 197/1221 | 16.1 | 151/1545 | 9.8 | <0.001 |
| History of smoking | 863/1374 | 62.8 | 628/967 | 64.9 | 235/407 | 57.7 | <0.001 |
| BMI ≥30 (kg/m2) | 251/1169 | 21.5 | 172/700 | 24.6 | 79/469 | 16.8 | <0.001 |
| SES/Low | 1569/2939 | 53.4 | 731/1315 | 55.6 | 838/1624 | 51.6 | 0.002 |
| Hypertension | 342/972 | 35.2 | 266/759 | 35.0 | 76/213 | 35.7 | 0.35 |
| GFR <60 mL/min/1.73 m2 | 24/2939 | 0.82 | 6/1315 | 0.46 | 18/1624 | 1.1 | <0.001 |
BMI, body mass index; CABG, coronary artery bypass grafting, CVD, cardiovascular disease; MI, myocardial infarction; GFR, glomerular filtration rate; nc, not calculated; PCI, percutaneous coronary intervention; SES, socioeconomic status; TC, total cholesterol; TG, triglycerides.
a Diabetes mellitus or fasting glucose ≥7 mmol/L or any glucose ≥11 mmol/L