Table 1. Effect of thoracic restraint and minodronate treatment on static and dynamic quantitative histomorphomety of thoracic spine.
| Controls | TR | ||||
|---|---|---|---|---|---|
| Vehicle | MIN | Vehicle | MIN | ||
| Bone structure | |||||
| BV/TV (%) | 20.0 ± 3.1 | 26.3 ± 2.7 | 11.5 ± 3.5 a | 24.5 ± 3.0 b | |
| Tb.Th (μm) | 38.6 ± 4.5 | 40.2 ± 2.0 | 26.0 ± 2.6 | 36.2 ± 2.0 b | |
| Tb.N (/mm) | 5.2 ± 0.6 | 6.5 ± 0.7 | 4.4 ± 0.9 a | 6.8 ± 0.7 b | |
| Tb.Sp (μm) | 156.2± 24.5 | 113.8 ± 14.7 | 210.5 ± 47.4 a | 112.9 ± 15.9 b | |
| Bone formation | |||||
| OS/BS (%) | 25.2 ± 6.1 | 13.5 ± 2.9 | 28.0 ± 5.5 | 17.3 ± 3.6 b | |
| Ob.S/BS (%) | 19.4 ± 6.2 | 7.4 ± 2.2 | 20.7 ± 5.1 | 10.5 ± 2.7 b | |
| O.Th (μm) | 2.44 ± 0.13 | 1.99 ± 0.19 | 2.73 ± 0.17 a | 1.99 ± 0.17 b | |
| Bone resorption | |||||
| ES/BS (%) | 29.2 ± 4.7 | 4.4 ± 2.2 | 34.4 ± 4.2 | 7.6 ± 2.9 b | |
| N.Oc/BS (/mm) | 3.2 ± 0.5 | 1.2 ± 0.3 | 4.4 ± 0.5 a | 1.2 ± 0.2 b | |
| Oc.S/BS (%) | 8.8 ± 1.0 | 2.7 ± 0.6 | 12.0 ± 1.7 a | 2.8 ± 0.4 b | |
| Bone dynamics | |||||
| MS/BS (%) | 26.3 ± 3.4 | 12.8 ± 3.8 | 30.5 ± 5.9 | 17.3± 2.8 b | |
| MAR (μm) | 1.82± 0.15 | 1.24 ± 0.22 | 2.04 ± 0.26 | 1.05 ± 0.22 b | |
| BFR/BS (μm3/μm2/year) | 174.2 ± 28.4 | 59.4 ± 25.0 | 230.0 ± 60.7 | 68.2 ± 22.3 b | |
BV/TV = bone volume fraction; Tb.Th = trabecular thickness; Tb.N = trabecular number; Tb.Sp = trabecular separation; OS/BS = osteoid surface per bone surface; Ob.S/BS = osteoblast surface per bone surface; O.Th = osteoid thickness; ES/BS = eroded surface per bone surface; N.Oc/BS = osteoclast number per bone surface; Oc.S/BS = osteoclast surface per bone surface; MS/BS = mineralizing surface per bone surface; MAR = mineral apposition rate; BFR/BS = bone formation rate per bone surface; TR = thoracic restraint; MIN = minodronate
Values are mean ± SD. (n = 6 for each group; a p < 0.05 TR versus control within vehicle condition. b p < 0.05 MIN versus Vehicle within TR condition.)