Table 4. Cox Analysis of determinants of renal death adjusted for baseline covariates (model 1) and adding time varying covariate (model 2: Model 1 + delta PTH) stratified by CKD stage and cohort dimension.

	Model 1		Model 2
	Hazard Ratio (95% C.I:)	P	Hazard Ratio (95% C.I.)	P
Age (years)	1.01 (0.99–1.03)	0.420	1.01 (0.99–1.03)	0.447
Males vs Females	1.92 (1.17–3.13)	0.010	1.90 (1.16–3.12)	0.010
Diabetes Yes vs No	1.21 (0.75–1.96)	0.445	1.25 (0.77–2.03)	0.373
CVD Yes vs No	1.83 (1.15–2.92)	0.011	1.86(1.17–2.96)	0.009
Hypertension Yes vs No	0.88 (0.20–3.87)	0.855	0.88 (0.20–3.88)	0.866
RAS* inhibitors Yes or No	0.81 (0.49–1.32)	0.409	0.72 (0.44–1.20)	0.219
Proteinuria (+1 g/day)	1.35 (1.14–1.61)	0.001	1.31 (1.10–1.55)	0.002
Serum Total Calcium (+1 mg/dL)	0.84 (0.57–1.25)	0.388	0.87 (0.59–1.28)	0.465
Serum Phosphate (+1 mg/dL)	1.46 (1.07–1.98)	0.015	1.39 (1.03–1.89)	0.035
Serum PTH (+10 pg/ml)	1.03 (1.01–1.04)	<0.0001	1.04 (1.02–1.05)	<0.0001
ΔPTH quartiles < -18 -18 to 0 0 to 18 >18 pg/mL	- - - -		Ref. 1.09 (0.47–2.55) 1.70 (0.74–3.89) 1.91 (1.08–3.38)	- 0.820 0.201 0.026

*RAS, Renin Angiotensin System