Table 1. Patient-years at risk and incidence rates for ICH by drug exposure group.
Antithrombotic treatment | Patients, No. | Patient-years at risk | Events, No. | Crude Rate, Events per 100 Person-Years (95% CI) | Age and sex adjusted incidence rate, Events per 100 Person-Years (95% CI) |
---|---|---|---|---|---|
None | 3108394 | 18498589.5 | 14056 | 0.076 (0.075–0.077) | 0.093 (0.091–0.094) |
Aspirin | 594761 | 1998423.3 | 4701 | 0.24 (0.23–0.24) | 0.12 (0.11–0.14) |
Warfarin | 151966 | 306658.9 | 1678 | 0.55 (0.52–0.57) | 0.28 (0.24–0.31) |
Aspirin plus Clopidogrel | 83593 | 72635.1 | 264 | 0.36 (0.32–0.41) | 0.20 (0.15–0.24) |
Aspirin-Dipyridamole | 59698 | 131792.9 | 650 | 0.49 (0.46–0.53) | 0.30 (0.19–0.40) |
Warfarin plus Aspirin | 54152 | 35035.2 | 263 | 0.75 (0.66–0.85) | 0.34 (0.26–0.43) |
Clopidogrel | 44771 | 43010.8 | 162 | 0.38 (0.32–0.44) | 0.25 (0.16–0.34) |
Rivaroxaban | 23532 | 17873.3 | 91 | 0.51 (0.41–0.63) | 0.26 (0.18–0.34) |
Dipyridamole | 22329 | 10868.0 | 49 | 0.45 (0.33–0.60) | 0.15 (0.098–0.21) |
Dabigatran | 18541 | 16176.3 | 40 | 0.25 (0.18–0.34) | 0.010 (0.057–0.13) |
Ticagrelor plus Aspirin | 11896 | 8829.8 | 25 | 0.28 (0.18–0.42) | 0.20 (0.098–0.31) |
Apixaban | 8202 | 2688.0 | 12 | 0.45 (0.23–0.78) | 0.17 (0.065–0.27) |
Warfarin plus Aspirin and Clopidogrel | 7682 | 2008.7 | 17 | 0.85 (0.49–1.36) | 0.33 (0.073–0.60) |
Dabigatran plus Aspirin | 6929 | 2487.3 | 10 | 0.40 (0.19–0.74) | 0.24 (0.028–0.45) |
Rivaroxaban plus Aspirin | 6740 | 2211.9 | 20 | 0.90 (0.55–1.40) | 0.36 (0.16–0.56) |
Aspirin-Dipyridamole plus Clopidogrel | 5835 | 1072.6 | 14 | 1.31 (0.71–2.19) | 0.44 (0.19–0.69) |
Other antithrombotic medication | 24734 | 9986.2 | 59 | 0.59 (0.45–0.76) | 0.25 (0.18–0.32) |
Patients could have multiple treatment courses with one drug or with different drugs.