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. 2018 Aug 23;13(8):e0202575. doi: 10.1371/journal.pone.0202575

Table 1. Patient-years at risk and incidence rates for ICH by drug exposure group.

Antithrombotic treatment Patients, No. Patient-years at risk Events, No. Crude Rate, Events per 100 Person-Years (95% CI) Age and sex adjusted incidence rate, Events per 100 Person-Years (95% CI)
None 3108394 18498589.5 14056 0.076 (0.075–0.077) 0.093 (0.091–0.094)
Aspirin 594761 1998423.3 4701 0.24 (0.23–0.24) 0.12 (0.11–0.14)
Warfarin 151966 306658.9 1678 0.55 (0.52–0.57) 0.28 (0.24–0.31)
Aspirin plus Clopidogrel 83593 72635.1 264 0.36 (0.32–0.41) 0.20 (0.15–0.24)
Aspirin-Dipyridamole 59698 131792.9 650 0.49 (0.46–0.53) 0.30 (0.19–0.40)
Warfarin plus Aspirin 54152 35035.2 263 0.75 (0.66–0.85) 0.34 (0.26–0.43)
Clopidogrel 44771 43010.8 162 0.38 (0.32–0.44) 0.25 (0.16–0.34)
Rivaroxaban 23532 17873.3 91 0.51 (0.41–0.63) 0.26 (0.18–0.34)
Dipyridamole 22329 10868.0 49 0.45 (0.33–0.60) 0.15 (0.098–0.21)
Dabigatran 18541 16176.3 40 0.25 (0.18–0.34) 0.010 (0.057–0.13)
Ticagrelor plus Aspirin 11896 8829.8 25 0.28 (0.18–0.42) 0.20 (0.098–0.31)
Apixaban 8202 2688.0 12 0.45 (0.23–0.78) 0.17 (0.065–0.27)
Warfarin plus Aspirin and Clopidogrel 7682 2008.7 17 0.85 (0.49–1.36) 0.33 (0.073–0.60)
Dabigatran plus Aspirin 6929 2487.3 10 0.40 (0.19–0.74) 0.24 (0.028–0.45)
Rivaroxaban plus Aspirin 6740 2211.9 20 0.90 (0.55–1.40) 0.36 (0.16–0.56)
Aspirin-Dipyridamole plus Clopidogrel 5835 1072.6 14 1.31 (0.71–2.19) 0.44 (0.19–0.69)
Other antithrombotic medication 24734 9986.2 59 0.59 (0.45–0.76) 0.25 (0.18–0.32)

Patients could have multiple treatment courses with one drug or with different drugs.