Table 1. Synergistic effect of the co-administered SIM and DMXAA on B16.F10 cells proliferation in the presence of TAMs.
| Treatment | IC50 | Confidence interval 95% | Combination index (CI) | |
|---|---|---|---|---|
| CI value | Interpretation | |||
| SIM | 4.825 | 1.232 to18.89 | - | - |
| DMXAA | 288.1 | 209.2 to 396.9 | - | - |
| SIM+100 μM DMXAA | 2.088 | 1.933 to 2.256 | 0.77 | Synergism |
IC50 represents the half maximal inhibitory concentration for the tested drugs and CI represents the “combination index”, which quantitatively depicts synergism (CI < 1), additive effect (CI = 1), and antagonism (CI > 1), according to Chou-Talalay method.