Skip to main content
. 2018 Aug 13;14(8):e1007463. doi: 10.1371/journal.pgen.1007463

Fig 4. The Stra8 promoter was activated by Wdr62 and JNK signaling.

Fig 4

(A) Stra8 expression was significantly induced by Wdr62 when retinoic acid (RA) was present. (B) Stra8 promoter activity could not be activated by either the WDR62 protein WD40 or JNK binding domain combined with RA treatment. (C) The AP-1 promoter was synergistically activated by Wdr62 transfection and RA treatment. (D) Stra8 mRNA levels were significantly increased in F9 cells when JNK1 and/or JNK2 was overexpressed. (E) Wdr62 was required for RA-induced JNK signaling activation. (F-G) Relative protein levels of WDR62 and P-JNK. Data are presented as the mean ± SEM (n = 3). ns, p > 0.05, *p < 0.05; and **p < 0.01.