Table 5. Sex distribution of HOMA-IR cut-off levels based on sensitivity and specificity for T2DM in different age groups.
| Age, yr | Incidence | AUC (95% CI) | P valuea | ROC coefficientsb | Youden index criteria | |
|---|---|---|---|---|---|---|
| Sensitivity, % | Specificity, % | |||||
| Men | ||||||
| 20–30s | 9 (1.7) | 0.804 (0.646–0.962) | .020 | −0.035 | 66.7 | 82.7 |
| 40s | 20 (5.9) | 0.842 (0.764–0.919) | 70.0 | 81.8 | ||
| 50s | 33 (8.2) | 0.869 (0.814–0.925) | 72.7 | 87.3 | ||
| 60s | 37 (11.1) | 0.704 (0.614–0.794) | 40.5 | 81.2 | ||
| 70s | 21 (8.1) | 0.736 (0.628–0.844) | 42.9 | 90.3 | ||
| Women | ||||||
| 20–30s | 11 (1.7) | 0.991 (0.982–1.000) | <0.001 | −0.092c | 100 | 82.3 |
| 40s | 12 (2.5) | 0.946 (0.898–0.993) | 91.7 | 86.1 | ||
| 50s | 19 (3.4) | 0.839 (0.748–0.930) | 73.7 | 81.9 | ||
| 60s | 25 (6.2) | 0.760 (0.648–0.872) | 68.0 | 76.6 | ||
| 70s | 28 (8.3) | 0.736 (0.656–0.816) | 57.1 | 70.8 | ||
Values are presented as number (%).
HOMA-IR, homeostasis model assessment of insulin resistance; T2DM, type 2 diabetes mellitus; AUC, area under the curve; CI, confidence interval; ROC, receiver-operating characteristic operation.
aP value for difference of AUC values between age group, bP value for linear trend of AUC values by age group, cP<0.05.