Table 1. Baseline characteristics.
Variable | Control (n=109) | T2DM (n=103) | P value |
---|---|---|---|
Age, yr | 48.9±14.7 | 52.2±12.4 | 0.070a |
Sex, male | 42 (38.5) | 58 (56.3) | 0.010b |
Height, cm | 162.5±9.6 | 164.3±9.0 | 0.168a |
Body weight, kg | 65.2±5.1 | 70.0±13.6 | 0.016a |
Waist circumference, cm | 84.4±11.0 | 88.7±11.6 | 0.049a |
Body mass index, kg/m2 | 24.5±4.1 | 25.9±4.1 | 0.018a |
Smoking status | |||
Current smoker | 8 (7.5) | 24 (24.2) | 0.001b |
Former smoker | 11 (10.4) | 15 (15.2) | 0.321b |
Never | 87 (82.1) | 60 (60.6) | 0.001b |
Hypertension | 18 (16.5) | 35 (34.0) | 0.003b |
Dyslipidemia | 19 (17.4) | 20 (19.4) | 0.709b |
Coronary artery disease | 10 (9.2) | 6 (5.8) | 0.356b |
Cerebrovascular disease | 1 (0.5) | 6 (5.8) | 0.059b |
Systolic BP, mm Hg | 128.7±15.1 | 134.4±17.9 | 0.014a |
Diastolic BP, mm Hg | 76.5±11.0 | 80.1±10.1 | 0.015a |
HbA1c, % | 5.5±0.4 | 8.2±2.2 | <0.001a |
Fasting glucose, mg/dL | 99.2±14.5 | 169.7±59.6 | <0.001a |
PP2 glucose, mg/dL | 127.9±34.7 | 311.2±99.8 | <0.001a |
Fasting C-peptide, pmol/mL | 0.70±0.36 | 0.90±0.38 | <0.001a |
PP2 C-peptide, pmol/mL | 3.38±1.42 | 2.74±1.48 | 0.003a |
Fasting insulin, µIU/mL | 9.39±5.21 | 11.79±6.72 | 0.005a |
PP2 insulin, µIU/mL | 65.32±66.80 | 49.54±45.60 | 0.059a |
HOMA-IR | 2.39±1.93 | 4.89±2.96 | <0.001a |
HOMA-β | 99.2±50.6 | 52.9±47.2 | <0.001a |
Apolipoprotein A, mg/dL | 131.7±29.8 | 121.7±28.7 | 0.089a |
Apolipoprotein B, mg/dL | 91.7±25.5 | 104.1±30.0 | 0.025a |
Triglyceride, mg/dL | 127.3±103.6 | 221.7±242.2 | <0.001a |
Total cholesterol, mg/dL | 190.5±37.8 | 203.3±52.2 | 0.046a |
Serum creatinine, mg/dL | 0.74±0.16 | 0.84±1.01 | 0.313a |
Estimated GFR | 104.5±20.7 | 115.9±59.6 | 0.068a |
HDL-C, mg/dL | 54.7±13.5 | 49.4±13.8 | 0.006a |
LDL-C, mg/dL | 117.5±34.6 | 124.6±47.8 | 0.229a |
sEGFR, ng/mL | 76.6±19.9 | 84.5±16.1 | 0.002a |
Values are presented as mean±standard deviation or number (%).
T2DM, type 2 diabetes mellitus; BP, blood pressure; HbA1c, glycosylated hemoglobin; PP2, 2-hour postprandial; HOMA-IR, homeostatic model assessment of insulin resistance; HOMA-β, homeostatic model assessment of β-cell function; GFR, glomerular filtration rate; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; sEGFR, soluble epidermal growth factor receptor.
aP value from independent t-test, bP value from chi-square test.