Fig. 1. Intraepidermal nerve fiber density and protein gene product (PGP) 9.5-positive small nerve fibers in the dorsum of nondiabetic and diabetic rats treated with or without empagliflozin. PGP-9.5 immunoreactive small nerve fibers were markedly decreased in the diabetes mellitus (DM) group. However, nerve fiber loss was significantly prevented in the empagliflozin-treated DM groups compared to the untreated DM group. Horizontal bar indicates 100 µm. NOR, normal plus vehicle treated group; IENFD, intraepidernal nerve fiber density. ^aP<0.05 vs. NOR, ^bP<0.05 vs. DM.