Fig. 4.

Effect of 1A on IOP levels in normotensive rabbits. a Dose-dependent effect on IOP of a single administration of 1A in normotensive NWZ rabbits. IOP was measured following 2 h. b Time-dependent effect on IOP of a single dose of 1A (100 μM) in normotensive NWZ rabbits. c Comparative analysis the maximal hypotensive effect of UDP and 1A (100 μM) in normotensive NWZ rabbits. d Comparative analysis of the effect on IOP of 1A (100 μM) and commercial drugs, xalatan (0.005%), trusopt (2%), and pilocarpine (2%), in normotensive NWZ rabbits. All values are the mean ± S.E.M. (n = 4–6) of three independent experiments and expressed as percentage of respective control. *P < 0.05 vs. control; **P < 0.01 vs. control; and ***P < 0.001 vs. control