Table 1.

Effect of 1A on cell viability, compared with timolol and trusopt in drug-treated human Y-79 retinoblastoma cells, rabbit NPE, SIRC cells, and human Huh7 cell cultures

Drug	Cell viability; IC50 (mM)
	Human Y79 RB	Rabbit NPE	Rabbit SIRC	Human Huh7
1A	216.3 ± 5.4	264.7 ± 5.2	216.3 ± 5.4	320.8 ± 3.2
Trusopt	70.8 ± 1.8*	193.7 ± 3.1*	nd	123.8 ± 8.8*
Timolol	19. 6 ± 0.8*	22.2 ± 0.6*	30.8 ± 0.3*	42.1 ± 0.6*

IC₅₀ values expressed as mM ± S.E.M, following administration of increasing concentrations (0.001–500 mM) of 1A, trusopt, and timolol. *P < 0.001 vs. 1A; one-way ANOVA with Tukey post-tests. nd not determined