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. 2018 Aug 23;8:12658. doi: 10.1038/s41598-018-30107-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of tumour cell migration and response to pathway inhibitors (10 days). Comparison of Wnt1 tumour cell migratory distance, from the anisotropic collagen scaffold nucleation point to within the scaffold, after 72 hours culture in the absence (a) or presence (b) of differentiated 3T3-L1 cells (known as ET-SIM), with/without pathway inhibitors ROCKi, GM6001 and Canertinib, all statistically compared to DMSO (vehicle control). The total number of migratory Wnt1 tumour cells within the scaffolds, in the absence (c) or presence (d) of differentiated 3T3-L1 cells (known as ET-SIM), with/without the pathway inhibitors ROCKi, GM6001 and Canertinib compared to DMSO (vehicle control). The following statistical analyses were applied: non-parametric unpaired/matching Kruskal-Wallis ANOVA with a Geisser-greenhouse correction combined with a Dunn’s multiple comparison test, *p < 0.05, ****p < 0.0001. Sample size n = 4.