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. 2018 Aug 23;8:12708. doi: 10.1038/s41598-018-31137-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SFN promotes the expression of genes involved in oxidative stress responses and redox signaling. MitoCHIP array-based analysis of anti-oxidative gene expression changes (A1). Most prominent/relevant gene expression were validated ad hoc by RT-PCR (A2). SFN treatment up-regulated the expression of Abc transporters (B1) and most relevant gene expression changes were validated ad hoc by RT-PCR (B2). N = 4 biological replicates per condition (assayed in triplicates). *p < 0.05, **p < 0.005 and ***p < 0.001 vs. controls (fold changes).