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. 2018 Aug 24;7(8):64. doi: 10.1038/s41389-018-0075-1

Fig. 4. MAPK and MAM-related interactome of PTPIP51 under Gefitinib, Lapatinib, Neratinib, and Mubritinib treatment.

Fig. 4

Interaction of Raf1 and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (a). Interaction of 14.3.3 and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (b). Interaction of c-Src and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (c). Interaction of PTP1B and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (d). Interaction of VAPB and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (e). Interaction of GSK3B and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (f). Interaction of Akt and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (g). Interaction of PKC and PTPIP51 in SK-BR3 and BT474 cells treated with 5 µM Gefitinib, 5 µM Lapatinib, 200 nM Neratinib, or 10 µM Mubritinib for 24 h (h). (N = 3)