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. 2018 Aug 23;8:12699. doi: 10.1038/s41598-018-30783-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nutritional meal replacement and prebiotic spike-ins result in reproducible changes across participants. (a) Schematic outlining the dietary and sampling regimen for the study. (b) OTUs that showed statistically significant (DESeq. 2, FDR < 0.1) differential abundance on day 6 compared to day 3 in response to particular spike-ins. Mean relative abundances are computed across all participants and then converted to Z-scores across timepoints, to illustrate relative changes through time. (c) OTUs that showed statistically significant (Wilcoxon Rank-Sum test, FDR < 0.1; N = 39) differential abundance on day 3 compared to baseline (preB). Complete RDP taxonomies can be found in Fig. S1.