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. 2018 Aug 23;4:34. doi: 10.1038/s41540-018-0068-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Transition path from A state to M state (a corresponding to the metastatic progression) and from M state to A state (b corresponding to the anti-metastatic progress) in terms of expression levels of 10 different genes. The relative gene expressions are discretized to 0 or 1. 1 represents that the corresponding genes are in the on (activated) state and 0 represents that the corresponding genes are in the off (repressed) state. X-axis shows the 10 time points along the transition path