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. 2018 Aug 23;9:3385. doi: 10.1038/s41467-018-05811-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Germline and somatic associations with drug susceptibility. a Negative log P values from genome-wide association analyses with drug susceptibility phenotypes of 265 drugs, either considering lead germline variants (x-axis) or lead somatic mutations (y-axis). Shown are lead associations, i.e., the most significant association for either QTL type for each drug. b Effect size estimates for the associations shown in a, considering the corresponding lead germline associations (x-axis) or lead somatic associations (y-axis). Each dot represents a drug. Drugs coloured in blue have a significant germline or somatic association (FWER < 0.05). Somatic QTLs tended to have large effect sizes than germline QTLs. (See also Supplementary Fig. 5 for an analysis stratified by variant frequency)