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. 2018 Aug 23;8:12680. doi: 10.1038/s41598-018-30881-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The toxicological impact of GLE treated tumor-bearing mice. (A) Pathological examination was used to detect toxic damage of liver and renal tissue in all groups. Sections of liver and renal tissue in mice were stained using HE followed by observation on a phase-contrast microscope (×400). Obvious changes are highlighted by arrows. The structure of the hepatic lobule was intact, and no inflammatory cell infiltration was found in the portal area and the liver proper. Six hours prior to sacrifice, mice had not been fasted, thus each group showed vacuoles in the liver cells. This simply indicated glycogen accumulation in the liver cells was not associated with pathology. Likewise, hypertrophy of hepatocytes around the central vein of the liver tissue in cisplatin group was attributed to damage to liver cells caused by cisplatin. (B,C) Effects of GLE on liver and renal indexes were analyzed in tumor-bearing mice. (D,E) GLE improves the suppression of bone marrow cells in tumor-bearing mice. FACS was used to detect the effects of GLE on the cell cycle progression of bone marrow. Representative results of three independent experiments are shown. Error bars, SD; ^*P < 0.05; ^**P < 0.01, versus control values; ^ΔP < 0.05; ^ΔΔP < 0.01, versus model values.