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. 2018 Aug 23;8:12706. doi: 10.1038/s41598-018-29711-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histology of prostate tumor xenografts. (a) Mice were euthanized and tumor tissues were collected for staining 72 h post AMF exposure (Row I: H&E, row II: Prussian blue and row III: silver enhancement stain). The control shows no iron oxide or gold present. Tissues from the mouse injected with JHU MIONs show iron oxide particles in the H&E stain, iron staining (blue) with Prussian blue and no response to the silver enhancement stain. Tissues from the mouse injected with AuSi-MIONs show a dark purple color from the gold nanoparticles in the H&E stain and iron staining (blue) with Prussian blue. Dark black staining of the AuSi-MIONs by the silver enhancement stain, which only stains metallic gold or silver, can be seen in row III. Whole tumor images are composites created from separate 4x images; magnified images were obtained at 20x.