Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 17;12:70. doi: 10.3389/fnana.2018.00070

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 García-Cabezas, Barbas and Zikopoulos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Post-translational histone modifications in the nuclei of cortical neurons. (A1–A12) Photomicrographs of cortical neurons in the primary visual cortex of the rhesus macaque labeled for H3K4met1-2-3 [Anti-mono/di/trimethyl-Histone H3 (Lys4), cat. #04-791, Millipore, Temecula, CA, United States], which shows a modification that facilitates gene expression; the nuclei of small and large neurons show intense H3K4met1-2-3 labeling with empty pockets that correspond to nucleoli and thick heterochromatin clumps. (B1–B12) Micrographs of cortical neurons in the primary visual cortex of the rhesus macaque labeled for H3K9met3 [Anti-trimethyl-Histone H3 (Lys9), cat. #07-442, Millipore], a repressive histone mark for gene expression; the labeling of H3K9met3 highlights heterochromatin grains and clumps with a distribution comparable to Nissl stained neurons (compare with Figures 2B1–B15). Calibration bar in (B12) applies to all panels.