Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 17;12:573. doi: 10.3389/fnins.2018.00573

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 At least a portion of this work is authored by EH, SS, KR, NS, MK, MI, SJ, and CP on behalf of the U.S. Government and, as regards EH, SS, KR, NS, MK, MI, SJ, CP, and the U.S. Government, is not subject to copyright protection in the United States.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Focal and sharply delineated regions of decreased diffusivity were observed in the majority of injured brains in this study in the absence of overt T2 abnormalities. Whole slice images from the same brain specimen obtained 1 day following mCCI are shown at the same slice level for T2 and Trace MRI maps (A) as well as immunohistochemistry stained sections (B). While T2 MRI of this brain was unremarkable, a prominent region of decreased Trace was found in the cortex near to the CCI site (red arrows) that colocalized with microgliosis revealed by Iba-1 staining and dendritic structural damage observed on MAP-2 staining. High magnification images are shown (bottom row) for both stains within the region of abnormal Trace (ipsi) and for the corresponding regions on the uninjured side (contra).