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. 2018 Aug 17;12:573. doi: 10.3389/fnins.2018.00573

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Copyright © 2018 At least a portion of this work is authored by EH, SS, KR, NS, MK, MI, SJ, and CP on behalf of the U.S. Government and, as regards EH, SS, KR, NS, MK, MI, SJ, CP, and the U.S. Government, is not subject to copyright protection in the United States.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Focal reductions of fractional anisotropy (FA) were identified for most brains after mCCI and generally corresponded to pathology of the white matter near to the site of injury. Whole slice and magnified images are shown for the same representative brain taken 1 week after injury at the same slice level of the FA map (A), H&E stained sections (B), and GFAP immunohistochemistry (C). Decreases in FA were in some cases visually observable (A, left column) and the shape of these abnormalities could be sharply defined by lateralized difference maps (A, middle column), which were then used to generate ROI masks for this type of abnormality in a semi-automated way (A, right). Cellular alterations in the same tissue region were subtle, but visually apparent by H&E staining (B) and more specifically found to involve astrocytosis by GFAP immunohistochemistry (C) in this specimen.