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. 2018 Aug 17;12:573. doi: 10.3389/fnins.2018.00573

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Copyright © 2018 At least a portion of this work is authored by EH, SS, KR, NS, MK, MI, SJ, and CP on behalf of the U.S. Government and, as regards EH, SS, KR, NS, MK, MI, SJ, CP, and the U.S. Government, is not subject to copyright protection in the United States.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tensor-based morphometry analysis of local volume changes following mCCI. For both a dorsal slice near to the CCI site (A,B) and a more ventral slice distant from the CCI site (C,D), DTI maps from the control template are shown for reference (A,C) and group averaged LogJ maps generated from conventional TBM using structural MRI registration and D-TBM using DTI-based registration are shown for each experimental group (B,D) with the same window scaling as indicated in the scale bar at bottom. Black arrows indicate regions of reduced volume, which are more apparent by D-TBM analysis and most prominent near to the CCI site during the acute period but found to be bilateral and widespread during the chronic period. Closer examination of D-TBM LogJ maps from 16 weeks after mCCI (E) reveals several regions of white matter (WM) volume reduction (black arrows, D-TBM) that are localized to particular tracts within the lager body of WM discernable by their orientation on DEC maps (white arrows) compared with homogeneous contrast on scalar maps (Trace, FA, and T2W MRI) resulting in less focal or absent conventional TBM findings (black arrows, TBM).