Figure 3.

Phylogenetic tree based on whole-genome sequences of Mycobacterium tuberculosis isolated from all pediatric diagnoses resulting from whole-genome sequencing (WGS)-confirmed transmission within British Columbia (BC) (n = 14), and all adult isolates related by 24-locus Mycobacterial Interspersed Repetitive Units–Variable Number Tandem Repeat (MIRU-VNTR). Genotypic clusters are indicated by colored bands. Pediatric (star) and adult (circle) cases are colored where genomic epidemiology identified a clear source case (n = 12). Pediatric cases resulting from community transmission from an unknown source are indicated with black stars (n = 2). Gray stars indicate 2 pediatric patients who belong to a MIRU-VNTR cluster frequently seen in BC, for whom WGS indicated their infections were acquired outside BC. Bold tip labels indicate Canadian-born individuals; plain tip labels indicate foreign-born individuals, and italicized tip labels indicate unknown birthplace. Canadian-born children with Canadian-born parents are annotated with “_C” and those with foreign-born parents with “_F”. Internal branches are labeled by lineage: Euro-American (EAm), East-Asian (EAs), EAI (East-Asian Indian), and Indo-Oceanic (IO).