. 2018 Jul 5;7(8):914–923. doi: 10.1530/EC-18-0172
This work is licensed under a Table 3.
Correlation of adherence with growth outcomes after 1 year of GH treatment using easypod for patients (A) overall and (B) who were GH naïve at start of easypod use.
| Growth outcome | GHD (n = 886) | SGA (n = 206) | Turner syndrome (n = 82) | Othera/missing (n = 16) | Overall (n = 1190) |
|---|---|---|---|---|---|
| (A) Easypod adherence data analysis set | |||||
| Change in height, n (missing) | 803 (83) | 188 (18) | 76 (6) | 14 (2) | 1081 (109) |
| Spearman’s product–moment correlation | 0.12 | 0.08 | 0.11 | −0.22 | 0.11 |
| P value | <0.001 | 0.283 | 0.329 | 0.454 | <0.001 |
| Change in height SDS, n (missing) | 803 (83) | 188 (18) | 76 (6) | 14 (2) | 1081 (109) |
| Spearman’s product–moment correlation | 0.14 | 0.13 | 0.05 | −0.32 | 0.13 |
| P value | <0.001 | 0.0870 | 0.6692 | 0.2668 | <0.001 |
| Height velocity, n (missing) | 803 (83) | 188 (18) | 76 (6) | 14 (2) | 1081 (109) |
| Spearman’s product–moment correlation | 0.13 | 0.17 | 0.17 | −0.09 | 0.14 |
| P value | <0.001 | 0.0196 | 0.1491 | 0.7708 | <0.001 |
| Height velocity SDS, n (missing) | 790 (96) | 187 (19) | 68 (14) | 14 (2) | 1059 (131) |
| Spearman’s product–moment correlation | 0.11 | −0.06 | 0.03 | −0.39 | 0.08 |
| P value | 0.002 | 0.4294 | 0.8121 | 0.1745 | 0.013 |
| Growth outcome | Idiopathic isolated GHD (n = 167) | Organic GHD (congenital) (n = 23) | Organic GHD (tumour) (n = 27) | Unspecified/non-GHDb (n = 391) | Overall (n = 608) |
| (B) Easypod adherence data analysis set – GH-naïve | |||||
| Change in height, n (missing) | 150 (16) | 19 (4) | 23 (4) | 374 (16) | 566 (40) |
| Spearman’s product–moment correlation | −0.04 | 0.28 | −0.32 | 0.13 | 0.07 |
| P value | 0.627 | 0.255 | 0.139 | 0.011 | 0.110 |
| Change in height SDS, n (missing) | 150 (16) | 19 (4) | 23 (4) | 373 (17) | 565 (41) |
| Spearman’s product–moment correlation | 0.02 | 0.18 | −0.26 | 0.16 | 0.09 |
| P Value | 0.794 | 0.457 | 0.236 | 0.002 | 0.025 |
| Height velocity, n (missing) | 150 (16) | 19 (4) | 23 (4) | 373 (17) | 565 (41) |
| Spearman’s product–moment correlation | 0.04 | 0.29 | −0.34 | 0.15 | 0.09 |
| P value | 0.632 | 0.237 | 0.114 | 0.005 | 0.028 |
| Height velocity SDS, n (missing) | 147 (19) | 18 (5) | 23 (4) | 362 (28) | 550 (56) |
| Spearman’s product–moment correlation | 0.06 | 0.18 | −0.29 | 0.10 | 0.06 |
| P value | 0.464 | 0.483 | 0.175 | 0.055 | 0.133 |
The P values provided were not adjusted for multiplicity of testing.
aOther indications include chronic renal failure/chronic kidney disease, short stature/slow growth and other; bnon-GHD included patients with GHD of unspecified origin in addition to non-GHD indications.
GH, growth hormone; GHD, growth hormone deficiency; SDS, standard deviation score; SGA, small for gestational age.