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. 2018 May 24;72(4):897–904. doi: 10.1007/s11418-018-1222-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Inhibitory effect of four among seven crude drugs constituting YKS on the efflux ratio across a Caco-2 cell monolayer of the P-gp substrate digoxin. The dose–response correlative formula and correction coefficient (R²) of each crude drug were determined by regression analysis. Each data point represents the mean ± SD (n = 4). Concentration reactivity was statistically evaluated by one-way ANOVA