Table 2.
The P-gp inhibition rate of seven crude drugs constituting YKS
| Crude drug | Composition ratio of crude drug in YKS (%) | Concentration of crude drug in YKS (μg/ml)a | Contribution rate (%)b |
|---|---|---|---|
| Uncariae uncis cum ramulus | 14.6 | 284 | 53.1 |
| Glycyrrhizae radix | 7.4 | 143 | 1.7 |
| Atractylodis lanceae rhizoma | 19.5 | 378 | 15.3 |
| Poria | 19.5 | 378 | 14.7 |
| Angelicae acutilobae radix | 14.6 | 284 | 3.0 |
| Cnidii rhizoma | 14.6 | 284 | 7.4 |
| Bupleuri radix | 9.8 | 189 | 4.8 |
| Total | 100.0 | 1,940 | 100.0 |
aConcentration of each crude drug in the IC50 concentration (1.94 mg/ml) of YKS extract was calculated from the composition ratio of seven crude drugs constituting YKS
bThe contribution rate of each crude drug was calculated as a percentage of the total inhibition at each concentration included in the YKS (IC50 concentration) by using the correlative formulas described in result section and Fig. 2