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. 2018 May 14;132(8):837–848. doi: 10.1182/blood-2017-11-814319

Figure 7.

Figure 7.

CTCF boundary regulates HOXA locus chromatin structure and gene expression. (A) Enrichment of downregulated genes involved in the HOXA9 regulatory pathway in CBS7/9+/− MOLM13 cells compared with WT control, as shown by GSEA. (B) Overlap between downregulated genes, as determined by comparing RNA-seq data obtained from CBS7/9+/− cells and the HOXA9-KD gene expression data set (accession number GSE13714). (C) A model depicts that the CBS7/9 chromatin boundary defines an aberrant posterior HOXA chromatin domain and coordinates oncogenic transcription programs for leukemic transformation and invasion.