Table 1.

Translational research overview.

Evaluation of the main circulating T cells, MDSC and of circulating dendritic cells (DCs)	Evaluation of cell subpopulations-specific interleukins	Evaluation of the major cytokines (as VEGF, TGF-beta, TNF-alpha, IFN-γ and IDO)	Evaluation of the main tumor associated antigens (TAA) inducible by ICD (as HSP70, HSP90, HMGB1, EpCAM)
Baseline	Baseline	Baseline	Baseline
1 day after RT	1 day after RT	1 day after RT	1 day after RT
At beginning of cycle 2	At beginning of cycle 2	At beginning of cycle 2
At disease progression	At disease progression	At disease progression

Abbreviations: MDSC = myeloid-derived suppressor cell, DCs = dendritic cells, VEGF = vascular endothelial growth factor, TGF-beta = transforming growth factor-beta, TNF-alpha = tumor necrosis factor-alpha, IFN-γ = interferon-gamma, IDO = indoleamine 2,3-DiOxygenase, ICD = immunogenic cell death, HSP70 = heat shock protein 70, HSP90 = heat shock protein 90, HMGB1 = high-mobility group box 1, EpCAM = epithelial cell adhesion molecule.