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. 2018 Aug 23;8:48. doi: 10.1186/s13578-018-0246-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — ATRA (1 µM) inhibited osteoclast precursor cells proliferation in presence or absence of BMP2/7 (5 or 50 ng/ml). Results of cell proliferation assay in RAW264.7 cell cultures (a). Cytotoxicity assay in BMM cell cultures (b), and RAW264.7 cell cultures (c). Values are mean ± SD, from three independent experiments. Significant effect of ATRA and/or BMP2/7 treatment, ****p < 0.0001, n.s. no significant difference