Figure 1.

Sequence alignment of photolyases from A. nidulans, E. coli, and T. thermophilus. The conserved residues are highlighted in blue. The residues in contact with FAD, 8-HDF, and MTHF are shown in yellow, green, and blue, respectively (6, 7). The residues in the active site and the positive residues around the hole are shown in red and highlighted in pink, respectively. The secondary structures, helices, and strands of T. thermophilus photolyase are shown in white and gray boxes under the sequences. The sequence of photolyase from T. thermophilus HB8 has been deposited in DNA Data Base in Japan (accession no. AB064548).