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. Author manuscript; available in PMC: 2018 Aug 24.
Published in final edited form as: Chem Res Toxicol. 2018 Jun 18;31(7):570–584. doi: 10.1021/acs.chemrestox.8b00005

Figure 5.

Figure 5

LC–MS/MS analysis of the putative sunitinib quinoneimine dansyl–GSH conjugate. Sunitinib (25 μM) was incubated with recombinant P450 1A2 Supersomes (20 nM) in the presence of an NADPH-regenerating system and supplemented with dansyl–GSH (1 mM) for 30 min. Shown is a representative product ion spectrum from LC–MS/MS analysis of the precursor ion m/z 935, corresponding to the quinoneimine dansyl–GSH conjugate. The predicted structure of the sunitinib quinoneimine dansyl–GSH conjugate is shown above.