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. 2018 Jul 28;31(3 Suppl):97S–214S. doi: 10.1293/tox.31.97S

Figure 49.

Figure 49.

Fibroplasia, sub-retinal; Hypertrophy and Hyperplasia, RPE; C57BL/6 mouse. The RPE layer is focally replaced by a linear array of fibrovascular tissue that extends into the subretinal space and adjacent retina. There is enlargement, proliferation and migration of RPE with pigment dispersion within the lesion. Also note the presence of glial cells within the retina and atrophy of the outer nuclear layer. [used with permission: Int. J. Mol. Sci. 2014, 15(6), 9372-9385; doi:10.3390/ijms15069372]