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Meningioma, optic nerve, extra-ocular orbital space; C57BL/6 mouse. Spindloid cells form interlacing bundles situated between the Harderian gland and the sclera (high magnification). Note the invasiveness of this tumor on low magnification (inset; overview of the eye). Tumor cells can be seen infiltrating the sclera, cornea, uvea, and retina. Tumor cells also surround the optic nerve and adjacent muscles (arrows). Associated with bromodichloromethane administration; NTP archives.
