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Inflammation, granulomatous; middle ear; guinea pig. Granulomatous inflammatory reaction against a spicule (nonstaining cleft, arrow) of tissue glue embedded in the tympanic membrane. This guinea pig had placement of a tympanic bulla cannula that was secured with tissue glue and suture. Note the macrophage associated with the spicule. TB = Tympanic bulla lumen; EEC External ear canal.
