Figure 1.

Teriflunomide's mode of action.

It has been well accepted that teriflunomide reduces the number of activated peripheral T and B lymphocytes, which could potentially infiltrate the central nervous system (CNS). Our new study provides evidence that local parenchymal teriflunomide concentrations could also positively affect oligodendroglial precursor cells by means of promoting cell differentiation, maturation and subsequent generation of myelin sheaths around previously demyelinated axons.