Figure 1.

Effect of XFZY on neurological and cognitive functions of rats with TBI.

(A) mNSS: Rats showed neurological deficits after TBI, while administration of XFZY (9 and 18 g/kg) significantly lowered mNSS on days 14 and 21 compared with the TBI group. (B) Escape latency in the Morris water maze: TBI group showed significantly longer escape latency compared with the sham group, while the 9 g/kg XFZY group showed a significantly reduced time on day 21 compared with the TBI group. Data are expressed as the mean ± SD (n = 6). Data were analyzed by repeated-measures analysis of variance (mNSS) or repeated-measures analysis of variance mixed model and two-way repeated-measures analysis of variance (Morris water maze task). #P < 0.05, ##P < 0.01, vs. sham group; **P < 0.01, vs. TBI group. XFZY: Xuefu Zhuyu decoction; TBI: traumatic brain injury; CCI: controlled cortical impact; mNSS: modified neurological severity score.