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. 2018 Aug;13(8):1352–1353. doi: 10.4103/1673-5374.235237

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Copyright: © Neural Regeneration Research

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The retinal ganglion cell (RGC) protective mechanisms of human periodontal ligament-derived stem cells (PDLSCs).

Human PDLSCs after intravitreal transplantation can survive and migrate to the RGC layer and even to the optic nerve. The RGC protective mechanisms of human PDLSCs are mediated by cell-cell interaction and neurotrophic factor secretion (brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3) and others) by human PDLSCs. The injured retina can positively feedback to human PDLSCs to enhance their secretion of BDNF.