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. 2018 Aug;13(8):1396–1407. doi: 10.4103/1673-5374.235293

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Scutellarin downregulated caspase-3 in the penumbra after cerebral ischemic injury.

(A) Immunofluorescence double-labeling for caspase-3 and NeuN: Capsase-3 is localized in the nuclei of apoptotic cells. NeuN is localized in the cytoplasm and perinuclear region of mature neurons. Scale bar: 100 μm. (B) Percentage of caspase-3⁺/NeuN⁺ cells in the penumbra region. Data are expressed as the mean ± SD (n = 3 per group; one-way analysis of variance followed by the Tukey-Kramer multiple comparison test). #P < 0.05, vs. MCAO group; *P < 0.05, vs. sham group. MCAO: Middle cerebral artery occlusion.