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Schematic representation of the function and mechanism of circ-CFH glioma cells. Circ-CFH expression was significantly upregulated in glioma cells compared to that in normal cells. Circ-CFH functions as a miR-149 sponge to regulate the miR-149/Akt1 pathway in glioma cells. Increased circ-CFH expression levels in glioma decreased the activity of miR-449a; therefore, upregulated Akt1 expression ultimately promoted glioma progression.
