Table 2.

Final PopPK Model Parameter Estimates and Bootstrap Results

Population PK Parameters	Final Model Results		Bootstrap Results
	Parameter Estimates	RSE*	Median Value	95% CI
Typical value forf-ara-a CL, L/h/15 kg	3.1	3.3	3.1	2.9-3.4
Effect of creatinine clearance on f-ara-a CL	.006	9.5	.006	.004-.008
Vc, L/kg	13.4	6.3	13.4	11.9-14.9
Intercompartmental CL, L/h/kg	2.2	10.4	2.20	1.8-2.6
Vp, L/15	13.4	4.8	13.3	12.3-14.4
Kin†	.005	15.4	.005	.004-.008
Time effect on kin	−.41	12.7	−.41	−.52-−.30
Kout‡	.09	7.2	.09	.08-.10
Interindividual variability on CL§ (% shrinkage)	31.7 (3.8)	7.8	31.6	26.4-36.0
Interindividual variability on Vc§ (% shrinkage)	38.3 (13.5)	21.9	39.8	24.4-56.1
Interindividual variability on Kin§ (% shrinkage)	81.9 (29.7)	10.8	81.1	60.0-97.6
f-ara-A residual unexplained variability§ (% shrinkage)	24.8 (10.7)	7.6	24.1	21.3-27.6
f-ara-ATP residual unexplained variability§ (% shrinkage)	71.5 (11.2)	9.5	71.1	63.2-78.8
Correlation	CL - Vc	.86	12.8
	CL - Kin	.29	25.9
	Vc -Kin	.59	20.9

RSE indicates relative standard error; Vc volume of the central compartment; Vp, volume of the peripheral compartment.

* Relative standard error expressed as % mean.

† First-order rate constant for drug moving from the central compartment to the intracellular compartment.

‡ First-order rate constant for drug moving out of the intracellular compartment.

§ Presented as %CV.