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. Author manuscript; available in PMC: 2018 Aug 24.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 24;22(5):1708–1725. doi: 10.1016/j.bmc.2014.01.020

Figure 2.

Figure 2.

Binding mode of compound 4 at the MRSA PK tetramer interface binding site; (a) a two-dimensional map (MOE software) of the binding interactions between 1 and the interface site based on its co-crystallization with MRSA PK. Green arrows depict hydrogen-accepting interactions between 4 and MRSA PK residues from the interface (left). (b) Modeled overlay of compound 10b with 4 in the MRSA binding site (right) (ICM software from PDB data file 3t07).