Table 4.

Inhibition of enzymatic activities of MRSA PK and human PK isoforms at 10 μM

Analogs	% Inhibition of MRSA PK	% Inhibition of human M1	% Inhibition of human M2	% Inhibition of human R	% Inhibition of human L
10b	84.9 (2)	10.3 (2)	0.1 (2)	18.3 (2)	7.9 (2)
10c	97.8	6.9	8.7	13.6	6.1
10i	71	12.3	0.5	24.4	9.8
10k	94.1	8.6	15.8	33.4	23.7
10l	97.6	11.1	2.3	20.7	8.2
12a	99.0	13.9	9.1	2.7	2.8
17	100.9	14.6	12.1	25.2	6.8
20a	100.1	3.2	1.7	26.1	16.8
20b	100.6	13.1	3.5	50.7	32.1
22a	89.8	12.4	3.0	21.6	7.8
22b	95.9	5.3	0.4	−5.5	−6.0
25c	86.3	19.5	8.7	27.8	14.0
27a	93.4	16.1	−0.9	23.8	12.9
28a	93.4	9.9	1.3	24.1	9.7
33d	86.2	9.5	6.8	0.0	−8.9
33e	62.2	7.3	14.6	13.5	4.3