. 2018 Aug 20;13:2483–2494. doi: 10.2147/COPD.S167192

Table 2.

Correlations between clinical features and the serum levels of IL-17, IL-10, and IL-35 in patients with stable COPD (N=75)

Parameter	Group	n	Level of IL-17			Level of IL-10			Level of IL-35
Parameter	Group	n	(M±SD, pg/mL)	Statistical value	P-value	(M±SD, pg/mL)	Statistical value	P-value	(M±SD, pg/mL)	Statistical value	P-value
Resources	Healthy control	30	40.77±16.07	−8.80	<0.001	320.63±33.46	14.81	<0.001	353.61±57.12	17.30	<0.001
Resources	Stable COPD	75	69.31±14.57			188.34±44.05			169.28±45.83
Gender	Male	47	70.71±15.89	1.077	0.285	187.97±45.29	−2.75	0.071	164.08±46.09	−1.27	0.207
Gender	Female	28	66.97±11.95			205.74±36.37			177.99±45.03
Age (years)	<70	33	65.41±16.40	−2.10	0.039	206.14±46.96	3.30	0.001	191.84±46.51	4.17	<0.001
Age (years)	≧70	42	72.38±12.31			174.35±36.41			151.55±31.76
Smoking	Yes	39	72.00±15.58	1.68	0.096	172.51±45.68	−3.47	0.001	158.12±48.8	−2.25	0.027
Smoking	No	36	66.39±12.99			205.48±35.43			181.36±39.72
GOLD grade	1	7	42.07±8.36	64.84	<0.001	267.86±25.76	74.61	<0.001	252.41±22.13	136.33	<0.001
	2	13	55.28±8.74			220.39±17.38			212.69±17.19
	3	29	71.61±6.34^*			194.24±15.80^*			172.67±11.82^*
	4	26	81.09±8.35^*			144.32±28.27^*			121.40±23.51^*
mMRC score	2	12	48.28±10.74	31.95	<0.001	247.05±32.76	24.31	<0.001	236.48±27.38	38.66	<0.001
	3	31	69.13±10.93^**			189.05±30.17			172.76±32.42^**
	4	32	77.37±10.59^**			165.63±38.77^**			169.27±45.89^**
Clinical history (years)	<10	25	58.89±16.35	16.86	<0.001	221.75±39.79	20.31	<0.001	203.32±37.21	27.63	<0.001
	≧10<20	21	69.41±9.81			188.18±33.32			178.08±30.07
	≧20	29	78.22±9.18^***			159.64±33.60^***			133.39±46.89^***

Notes: For IL-17: ^*, GOLD grades 3 and 4 compared with GOLD grades 1 and 2; ^**, mMRC scores of 3 and 4 compared with mMRC score of 2; ^***, a clinical history of ≥20 years compared with a history of <10 years. For IL-10: ^*, GOLD grades 3 and 4 compared with GOLD grades 1 and 2; ^**, mMRC score of 4 compared with mMRC scores of 3 and 2; ^***, a clinical history of ≥20 years compared with a history of <10 years. For IL-35: ^*, GOLD grades 3 and 4 compared with GOLD grades 1 and 2; ^**, mMRC scores of 4 and 3 compared with mMRC score of 2; ^***, a clinical history of ≥20 years compared with a history of <20 years.

Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global initiative for chronic Obstructive Lung Disease; IL, interleukin; mMRC, modified British Medical Research Council.