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Kinetics of the interaction between the FVIIa variants and sTF
| FVIIa variant | kon, × 105 M−1⋅s−1 | koff, × 10−3 s−1 | Kd, nM |
|---|---|---|---|
| Wild-type FVIIa | 9.3 ± 0.3 | 2.1 ± 0.2 | 2.3 |
| K337A-FVIIa | 8.9 ± 1.1 | 1.7 ± 0.2 | 1.9 |
| FVIIaIIa | 9.6 ± 1.3 | 1.4 ± 0.2 | 1.5 |
Values are means ± SD (n = 3). Kd (koff/kon) values are calculated from the means.
