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Rate of inhibition of FVIIa variants by AT in the presence of heparin
| FVIIa variant | Residual activity after 15 min, % |
|---|---|
| Wild-type FVIIa | 80 ± 7 |
| K337A-FVIIa | 41 ± 6 |
| L305V/K337A-FVIIa | 23 ± 5 |
| FVIIaIIa | 22 ± 5 |
| K337A-FVIIaIIa | 13 ± 4 |
| L305V-FVIIaIIa | 19 ± 4 |
| L305V/K337A-FVIIaIIa | 9 ± 3 |
| M298Q-FVIIa | 47 ± 6 |
Values are means ± SD (n = 3).
