Figure 4.

Evidence that Intestinal Autophagy Promotes Intestinal Atrophy and PLP Accumulation

(A) Mutations in autophagy genes reduce age-associated PLP accumulation (left) and limit intestinal atrophy (right); N = 2 trials. All mutants were significantly different (p < 0.05) at 2 or more time points.

(B) atg-13 RNAi suppresses the age increase in intestinal autophagy (p = 0.009, 2-way ANOVA). mFP/dFP, monomeric fluorescent protein, dual fluorescent protein.

(C) Adult-limited atg-13 RNAi targeted to the gut reduces age-associated PLP accumulation (left) and intestinal atrophy (right); N = 2 trials.

(D) Adult-limited atg-13 RNAi rescues PLP accumulation and gut atrophy in mab-3 males; N = 3 trials.

^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. See also Figure S5.