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. 2018 Aug 20;28(16):2544–2556.e5. doi: 10.1016/j.cub.2018.06.035

Figure 6.

Figure 6

Intestinal Autophagy Promotes Optimal Reproduction at the Expense of Longevity

(A) Correlation between intestinal atrophy and lifespan. Left: individual worm analysis, day 7 gut width. Right: worm population analysis, different treatments affecting lifespan, day 6/7 gut width.

(B) Adult-limited atg-13 RNAi targeted to the whole animal extends lifespan; N = 6 trials.

(C) Adult- and gut-limited atg-13 RNAi extends lifespan; N = 5 trials.

(D) Inhibition of yolk synthesis extends lifespan; N = 5 trials.

(E) Inhibition of fatty acid synthesis shortens lifespan; N = 2 trials. Previously, no effect of fat-6(tm331); fat-7(wa36) on lifespan was detected [51]; the reason for the different effects of fat-6/7 RNAi and mutation remains unknown.

(F) mab-3; him-5 males are short lived but mab-3; him-5 hermaphrodites are not; N = 2 trials. Reduced lifespan of mab-3 males could be attributable to the visceral or the tail abnormalities.

(G) Adult-limited vit-5/6 RNAi (left) or atg-13 RNAi and atg-13 mutation (center) each modestly reduces brood size, but combined vit-5/6 RNAi and atg-13(bp414) cause sterility (right); N = 2 trials.

Experiments were performed at 20°C without FUDR (A and F), 25°C without FUDR (D, E, and G), and 25°C with FUDR (B and C). ∗p < 0.05, ∗∗∗p < 0.001. See also Figure S6 and Data S3.