Skip to main content
. Author manuscript; available in PMC: 2018 Sep 19.
Published in final edited form as: Nature. 2018 Mar 19;555(7698):623–628. doi: 10.1038/nature25979

Extended Data Figure 10. Drugs with anticommensal activity for all hierarchy levels of the ATC classification system.

Extended Data Figure 10

Fraction of drugs with anticommensal activity for all indication areas of the ATC classification scheme with a high fraction of active compounds. Shown are indication areas that contain at least two active compounds and a fraction of at least 50% active compounds, their parent terms and all top-level indication areas. Significance (p-value, one-sided Fischer’s exact test) is indicated by the bar color and corrected for multiple hypothesis testing (Benjamini-Hochberg) independently at each hierarchy level of the ATC. Many smaller classes, including PPIs (A02BC), non-selective calcium channel blockers (C08E), synthetic estrogens (G03CB), leukotriene receptor antagonists (R03DC) and phenothiazine and other antihistamines (R06AD & R06AX) are enriched, but due to multiple testing and small numbers of drugs tested in each group, they do not reach a significant p-value.